TY - JOUR
T1 - Transient blood flow in elastic coronary arteries with varying degrees of stenosis and dilatations: CFD modelling and parametric study
AU - Wu, J.
AU - Liu, G.
AU - Huang, W.
AU - Ghista, D.N.
AU - Wong, Kelvin
PY - 2015
Y1 - 2015
N2 - © 2014, © 2014 Taylor & Francis. In this paper, we have analysed pulsatile flow through partially occluded elastic arteries, to determine the haemodynamic parameters of wall shear stress (WSS), wall pressure gradient and pressure drops (ΔP), contributing to enhanced flow resistance and myocardial ischaemic regions which impair cardiac contractility and cause increased work load on the heart. In summary, it can be observed that stenoses in an artery significantly influence the haemodynamic parameters of wall shear stress and pressure drop in contrast to dilatations case. This deduces that stenosis plays a more critical role in plaque growth and vulnerability in contrast to dilatation, and should be the key element in cardiovascular pathology and diagnosis. Through quantitative analysis of WSS and ΔP, we have provided a clearer insight into the haemodynamics of atherosclerotic arteries. Determination of these parameters can be helpful to cardiologists, because it is directly implicated in the genesis and development of atherosclerosis.
AB - © 2014, © 2014 Taylor & Francis. In this paper, we have analysed pulsatile flow through partially occluded elastic arteries, to determine the haemodynamic parameters of wall shear stress (WSS), wall pressure gradient and pressure drops (ΔP), contributing to enhanced flow resistance and myocardial ischaemic regions which impair cardiac contractility and cause increased work load on the heart. In summary, it can be observed that stenoses in an artery significantly influence the haemodynamic parameters of wall shear stress and pressure drop in contrast to dilatations case. This deduces that stenosis plays a more critical role in plaque growth and vulnerability in contrast to dilatation, and should be the key element in cardiovascular pathology and diagnosis. Through quantitative analysis of WSS and ΔP, we have provided a clearer insight into the haemodynamics of atherosclerotic arteries. Determination of these parameters can be helpful to cardiologists, because it is directly implicated in the genesis and development of atherosclerosis.
U2 - 10.1080/10255842.2014.976812
DO - 10.1080/10255842.2014.976812
M3 - Article
VL - 18
SP - 1835
EP - 1845
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
SN - 1025-5842
IS - 16
ER -