Transforming growth factor-beta in pleural fibrosis

Yun Lee

doi:10.26182/5d538c2cfbb40

Transforming growth factor-beta in pleural fibrosis

Yun Lee

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated] The pleura is involved in a wide range of pulmonary and systemic disorders. Patients with pleural diseases commonly present with pleural effusions. As many as 1 in 1500 adults each year undergo pleurodesis, the iatrogenic induction of pleural fibrosis to obliterate the pleural space, for the management of recurrent pleural effusions and pneumothoraces. Chemical pleurodesis is performed by intrapleural injection of a sclerosing agent (eg talc or tetracycline derivatives) that induces acute inflammatory response and subsequent fibrosis. Currently available agents are either sub-optimal in efficacy or have significant side effects, especially pain and fever from acute pleural inflammation. Transforming Growth Factor (TGF)-? is a unique cytokine with potent profibrotic and immunomodulatory functions. Its effect in the pleura is unknown. The hypothesis that TGF? can induce pleurodesis effectively, promptly and safely without causing significant pleural inflammation was investigated.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
DOIs	https://doi.org/10.26182/5d538c2cfbb40
Publication status	Unpublished - 2002

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This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact digitaltheses-lib@uwa.edu.au

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10.26182/5d538c2cfbb40

Lee_Y_C_Gary_2002
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Cite this

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title = "Transforming growth factor-beta in pleural fibrosis",

abstract = "[Truncated] The pleura is involved in a wide range of pulmonary and systemic disorders. Patients with pleural diseases commonly present with pleural effusions. As many as 1 in 1500 adults each year undergo pleurodesis, the iatrogenic induction of pleural fibrosis to obliterate the pleural space, for the management of recurrent pleural effusions and pneumothoraces. Chemical pleurodesis is performed by intrapleural injection of a sclerosing agent (eg talc or tetracycline derivatives) that induces acute inflammatory response and subsequent fibrosis. Currently available agents are either sub-optimal in efficacy or have significant side effects, especially pain and fever from acute pleural inflammation. Transforming Growth Factor (TGF)-? is a unique cytokine with potent profibrotic and immunomodulatory functions. Its effect in the pleura is unknown. The hypothesis that TGF? can induce pleurodesis effectively, promptly and safely without causing significant pleural inflammation was investigated.",

author = "Yun Lee",

note = "This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact digitaltheses-lib@uwa.edu.au",

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doi = "10.26182/5d538c2cfbb40",

language = "English",

school = "The University of Western Australia",

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N1 - This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact digitaltheses-lib@uwa.edu.au

PY - 2002

Y1 - 2002

N2 - [Truncated] The pleura is involved in a wide range of pulmonary and systemic disorders. Patients with pleural diseases commonly present with pleural effusions. As many as 1 in 1500 adults each year undergo pleurodesis, the iatrogenic induction of pleural fibrosis to obliterate the pleural space, for the management of recurrent pleural effusions and pneumothoraces. Chemical pleurodesis is performed by intrapleural injection of a sclerosing agent (eg talc or tetracycline derivatives) that induces acute inflammatory response and subsequent fibrosis. Currently available agents are either sub-optimal in efficacy or have significant side effects, especially pain and fever from acute pleural inflammation. Transforming Growth Factor (TGF)-? is a unique cytokine with potent profibrotic and immunomodulatory functions. Its effect in the pleura is unknown. The hypothesis that TGF? can induce pleurodesis effectively, promptly and safely without causing significant pleural inflammation was investigated.

AB - [Truncated] The pleura is involved in a wide range of pulmonary and systemic disorders. Patients with pleural diseases commonly present with pleural effusions. As many as 1 in 1500 adults each year undergo pleurodesis, the iatrogenic induction of pleural fibrosis to obliterate the pleural space, for the management of recurrent pleural effusions and pneumothoraces. Chemical pleurodesis is performed by intrapleural injection of a sclerosing agent (eg talc or tetracycline derivatives) that induces acute inflammatory response and subsequent fibrosis. Currently available agents are either sub-optimal in efficacy or have significant side effects, especially pain and fever from acute pleural inflammation. Transforming Growth Factor (TGF)-? is a unique cytokine with potent profibrotic and immunomodulatory functions. Its effect in the pleura is unknown. The hypothesis that TGF? can induce pleurodesis effectively, promptly and safely without causing significant pleural inflammation was investigated.

U2 - 10.26182/5d538c2cfbb40

DO - 10.26182/5d538c2cfbb40

M3 - Doctoral Thesis

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