Transferrin receptor 2: a new molecule in iron metabolism

    Research output: Contribution to journalArticle

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    Abstract

    Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals. Recently, a close homologue of human transferrin receptor 1 was cloned and called transferrin receptor 2 (TfR2). A similar molecule has been identified in the mouse. Human transferrin receptor 2 is 45% identical with transferrin receptor 1 in the extracellular domain, but contains no iron responsive element in its mRNA and is apparently not regulated by intracellular iron concentration nor by interaction with HFE. Transferrin receptor 2, like transferrin receptor 1, binds transferrin in a pH-dependent manner (but with 25 times lower affinity) and delivers iron to cells. However, transferrin receptor 2 distribution differs from transferrin receptor 1, increasing in differentiating hepatocytes and decreasing in differentiating erythroblasts. Expression of both receptors is cell cycle dependent. Mutations in the human transferrin receptor 2 gene cause iron overload disease, suggesting it has a role in iron homeostasis. (C) 2002 Elsevier Science Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)292-296
    JournalInternational Journal of Biochemistry & Cell Biology
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 2003

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    Transferrin Receptors
    Metabolism
    Iron
    Molecules
    Transferrin
    Erythroblasts
    Mammals
    Iron Overload
    Hepatocytes
    Cell Cycle
    Homeostasis
    Genes
    Cells
    Messenger RNA
    Mutation

    Cite this

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    title = "Transferrin receptor 2: a new molecule in iron metabolism",
    abstract = "Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals. Recently, a close homologue of human transferrin receptor 1 was cloned and called transferrin receptor 2 (TfR2). A similar molecule has been identified in the mouse. Human transferrin receptor 2 is 45{\%} identical with transferrin receptor 1 in the extracellular domain, but contains no iron responsive element in its mRNA and is apparently not regulated by intracellular iron concentration nor by interaction with HFE. Transferrin receptor 2, like transferrin receptor 1, binds transferrin in a pH-dependent manner (but with 25 times lower affinity) and delivers iron to cells. However, transferrin receptor 2 distribution differs from transferrin receptor 1, increasing in differentiating hepatocytes and decreasing in differentiating erythroblasts. Expression of both receptors is cell cycle dependent. Mutations in the human transferrin receptor 2 gene cause iron overload disease, suggesting it has a role in iron homeostasis. (C) 2002 Elsevier Science Ltd. All rights reserved.",
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    Transferrin receptor 2: a new molecule in iron metabolism. / Trinder, Debbie; Baker, Erica.

    In: International Journal of Biochemistry & Cell Biology, Vol. 35, No. 3, 2003, p. 292-296.

    Research output: Contribution to journalArticle

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    AU - Baker, Erica

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