Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?

Megan Kummrow, Steven Hiho, Fiona Hudson, Linda Cantwell, William R Mulley, Lloyd D'Orsogna, Adam Testro, Julie Pavlovic, Peter MacDonald, Lucy C Sullivan, Gregory I Snell, Glen P Westall

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.

Original languageEnglish
Pages (from-to)1577-1581
Number of pages5
JournalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume19
Issue number5
DOIs
Publication statusPublished - May 2019
Externally publishedYes

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