Transdifferentiation of myoblasts into osteoblasts – possible use for bone therapy

D.P.L. Lin, Revathy Carnagarin, Arun Dharmarajan, C.R. Dass

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Objectives: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful. Key findings: The potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation. Summary: This potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours.

Original languageEnglish
Pages (from-to)1661-1671
Number of pages11
JournalJournal of Pharmacy and Pharmacology
Volume69
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

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