Trans-repression of β-Catenin Activity by Nuclear Receptors

Salimuddin Shah, Andreas Hecht, Richard Pestell, Stephen W. Byers

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)

Abstract

The signaling/oncogenic activity of β-catenin can be repressed by the activation of nuclear receptors such as the vitamin A, vitamin D, and androgen receptors. Although these receptors directly interact with β-catenin and can sequester it away from its transcription factor partner T-cell factor, it is not known if this is the mechanism of trans-repression. Using several different promoter constructs and nuclear receptors and mammalian two-hybrid and mutation analyses we now show that interaction with the co-activator, p300, underlies the trans-repression of β-catenin signaling by nuclear receptors and their ligands.

Original languageEnglish
Pages (from-to)48137-48145
Number of pages9
JournalJournal of Biological Chemistry
Volume278
Issue number48
DOIs
Publication statusPublished - 28 Nov 2003
Externally publishedYes

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