TY - JOUR
T1 - Trajectories of Irregular Word Reading ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging
T2 - A Longitudinal Study
AU - Weinborn, Michael George
AU - Bucks, Romola Starr
AU - Sohrabi, Hamid
AU - Rainey Smith, Stephanie Ruth
AU - Brown, Belinda M.
AU - Gardener, Samantha
AU - Gozt, A.
AU - Christensen, D
AU - Savage, G.
AU - Laws, S.
AU - Taddei, K
AU - Maruff, P
AU - Robertson, J.
AU - Ellis, K.
AU - Ames, D.
AU - Masters, C
AU - Rowe, C
AU - Martins, R
PY - 2018/10
Y1 - 2018/10
N2 - he ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer�s disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3.01 and 7.39 fewer words, respectively, than healthy controls. The MCI group�s performance remained stable during the study, but the AD group declined. Importantly, the observed decline was likely an underestimate, as significant numbers of the AD participants (42.6%) could not complete the task at follow-up. Use of alternate (e.g., demographics-based) methods is advised to augment or replace word pronunciation in estimating premorbid intelligence in individuals with even mild AD. © 2018 American Psychological Association.
AB - he ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer�s disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3.01 and 7.39 fewer words, respectively, than healthy controls. The MCI group�s performance remained stable during the study, but the AD group declined. Importantly, the observed decline was likely an underestimate, as significant numbers of the AD participants (42.6%) could not complete the task at follow-up. Use of alternate (e.g., demographics-based) methods is advised to augment or replace word pronunciation in estimating premorbid intelligence in individuals with even mild AD. © 2018 American Psychological Association.
U2 - 10.1037/pas0000565
DO - 10.1037/pas0000565
M3 - Article
C2 - 29781669
SN - 1040-3590
VL - 30
SP - 1308
EP - 1316
JO - Psychological Assessment
JF - Psychological Assessment
IS - 10
ER -