Trajectories of Irregular Word Reading ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study

Michael George Weinborn, Romola Starr Bucks, Hamid Sohrabi, Stephanie Ruth Rainey Smith, Belinda M. Brown, Samantha Gardener, A. Gozt, D Christensen, G. Savage, S. Laws, K Taddei, P Maruff, J. Robertson, K. Ellis, D. Ames, C Masters, C Rowe, R Martins

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Abstract

he ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer�s disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3.01 and 7.39 fewer words, respectively, than healthy controls. The MCI group�s performance remained stable during the study, but the AD group declined. Importantly, the observed decline was likely an underestimate, as significant numbers of the AD participants (42.6%) could not complete the task at follow-up. Use of alternate (e.g., demographics-based) methods is advised to augment or replace word pronunciation in estimating premorbid intelligence in individuals with even mild AD. © 2018 American Psychological Association.
Original languageEnglish
Number of pages9
JournalPsychological Assessment
DOIs
Publication statusE-pub ahead of print - 21 May 2018

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