Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson's Disease Cohort

Ashani Jeyadevan, Megan C. Bakeberg, Michelle Byrnes, Jade Kenna, Soumya Ghosh, Rick Stell, Sue Walters, Tess Evans, Sarah McGregor, Malcolm Horne, Frank L. Mastaglia, Ryan S. Anderton

Research output: Contribution to journalArticle

Abstract

Introduction. Patients with Parkinson's disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods. A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results. The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention p=0.137, cognitive instability p=0.787, self-control p=0.503, cognitive complexity p=0.157, motor impulsivity p=0.559, or perseverance p=0.734 between the PD-MCI and PD-C groups. Conclusions. These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.

Original languageEnglish
Article number2672075
JournalParkinson's Disease
Volume2019
DOIs
Publication statusPublished - 1 Jan 2019

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Impulsive Behavior
Parkinson Disease
Cognitive Dysfunction
Disruptive, Impulse Control, and Conduct Disorders
Movement Disorders
Cognition

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Jeyadevan, Ashani ; Bakeberg, Megan C. ; Byrnes, Michelle ; Kenna, Jade ; Ghosh, Soumya ; Stell, Rick ; Walters, Sue ; Evans, Tess ; McGregor, Sarah ; Horne, Malcolm ; Mastaglia, Frank L. ; Anderton, Ryan S. / Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson's Disease Cohort. In: Parkinson's Disease. 2019 ; Vol. 2019.
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Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson's Disease Cohort. / Jeyadevan, Ashani; Bakeberg, Megan C.; Byrnes, Michelle; Kenna, Jade; Ghosh, Soumya; Stell, Rick; Walters, Sue; Evans, Tess; McGregor, Sarah; Horne, Malcolm; Mastaglia, Frank L.; Anderton, Ryan S.

In: Parkinson's Disease, Vol. 2019, 2672075, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson's Disease Cohort

AU - Jeyadevan, Ashani

AU - Bakeberg, Megan C.

AU - Byrnes, Michelle

AU - Kenna, Jade

AU - Ghosh, Soumya

AU - Stell, Rick

AU - Walters, Sue

AU - Evans, Tess

AU - McGregor, Sarah

AU - Horne, Malcolm

AU - Mastaglia, Frank L.

AU - Anderton, Ryan S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction. Patients with Parkinson's disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods. A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results. The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention p=0.137, cognitive instability p=0.787, self-control p=0.503, cognitive complexity p=0.157, motor impulsivity p=0.559, or perseverance p=0.734 between the PD-MCI and PD-C groups. Conclusions. These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.

AB - Introduction. Patients with Parkinson's disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods. A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results. The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention p=0.137, cognitive instability p=0.787, self-control p=0.503, cognitive complexity p=0.157, motor impulsivity p=0.559, or perseverance p=0.734 between the PD-MCI and PD-C groups. Conclusions. These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.

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U2 - 10.1155/2019/2672075

DO - 10.1155/2019/2672075

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JO - Parkinson's Disease

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SN - 2042-0080

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