Tracking of airway and tissue mechanics during TLC maneuvers in mice

Zoltan Hantos, R.A. Collins, Debra Turner, T.Z. Janosi, Peter Sly

Research output: Contribution to journalArticle

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Abstract

A tracking impedance estimation technique was developed to follow the changes in total respiratory impedance (Zrs) during slow total lung capacity maneuvers in six anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with the wave-tube technique and pseudorandom forced oscillations at nine frequencies between 4 and 38 Hz during inflation from a transrespiratory pressure of 0-20 cmH(2)O and subsequent deflation, each lasting for similar to20 s. Zrs was averaged for 0.125 s and fitted by a model featuring airway resistance ( Raw) and inertance, and tissue damping and elastance ( H). Lower airway conductance (Glaw) was linearly related to volume above functional residual capacity (V) between 0 and 75 - 95% maximum V, with a mean slope of dGlaw/dV = 13.6 +/- 4.6 cmH(2)O(-1) . s(-1). The interdependence of Raw and H was characterized by two distinct and closely linear relationships for the low- and high-volume regions, separated at similar to 40% maximum V. Comparison of Raw with the highest-frequency resistance of the total respiratory system revealed a marked volume-dependent contribution of tissue resistance to total respiratory system resistance, resulting in the overestimation of Raw by 19 +/- 8 and 163 +/- 40% at functional residual capacity and total lung capacity, respectively, whereas the lowest frequency reactance was proportional to H; these findings indicate that single- frequency resistance values may become inappropriate as surrogates of Raw when tissue impedance is changing.
Original languageEnglish
Pages (from-to)1695-1705
JournalJournal of Applied Physiology
Volume95
Issue number4
DOIs
Publication statusPublished - 2003

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Mechanics
Electric Impedance
Total Lung Capacity
Functional Residual Capacity
Respiratory System
Airway Resistance
Economic Inflation
Pressure

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Hantos, Zoltan ; Collins, R.A. ; Turner, Debra ; Janosi, T.Z. ; Sly, Peter. / Tracking of airway and tissue mechanics during TLC maneuvers in mice. In: Journal of Applied Physiology. 2003 ; Vol. 95, No. 4. pp. 1695-1705.
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abstract = "A tracking impedance estimation technique was developed to follow the changes in total respiratory impedance (Zrs) during slow total lung capacity maneuvers in six anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with the wave-tube technique and pseudorandom forced oscillations at nine frequencies between 4 and 38 Hz during inflation from a transrespiratory pressure of 0-20 cmH(2)O and subsequent deflation, each lasting for similar to20 s. Zrs was averaged for 0.125 s and fitted by a model featuring airway resistance ( Raw) and inertance, and tissue damping and elastance ( H). Lower airway conductance (Glaw) was linearly related to volume above functional residual capacity (V) between 0 and 75 - 95{\%} maximum V, with a mean slope of dGlaw/dV = 13.6 +/- 4.6 cmH(2)O(-1) . s(-1). The interdependence of Raw and H was characterized by two distinct and closely linear relationships for the low- and high-volume regions, separated at similar to 40{\%} maximum V. Comparison of Raw with the highest-frequency resistance of the total respiratory system revealed a marked volume-dependent contribution of tissue resistance to total respiratory system resistance, resulting in the overestimation of Raw by 19 +/- 8 and 163 +/- 40{\%} at functional residual capacity and total lung capacity, respectively, whereas the lowest frequency reactance was proportional to H; these findings indicate that single- frequency resistance values may become inappropriate as surrogates of Raw when tissue impedance is changing.",
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Hantos, Z, Collins, RA, Turner, D, Janosi, TZ & Sly, P 2003, 'Tracking of airway and tissue mechanics during TLC maneuvers in mice' Journal of Applied Physiology, vol. 95, no. 4, pp. 1695-1705. https://doi.org/10.1152/japplphysiol.00104.2003

Tracking of airway and tissue mechanics during TLC maneuvers in mice. / Hantos, Zoltan; Collins, R.A.; Turner, Debra; Janosi, T.Z.; Sly, Peter.

In: Journal of Applied Physiology, Vol. 95, No. 4, 2003, p. 1695-1705.

Research output: Contribution to journalArticle

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T1 - Tracking of airway and tissue mechanics during TLC maneuvers in mice

AU - Hantos, Zoltan

AU - Collins, R.A.

AU - Turner, Debra

AU - Janosi, T.Z.

AU - Sly, Peter

PY - 2003

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AB - A tracking impedance estimation technique was developed to follow the changes in total respiratory impedance (Zrs) during slow total lung capacity maneuvers in six anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with the wave-tube technique and pseudorandom forced oscillations at nine frequencies between 4 and 38 Hz during inflation from a transrespiratory pressure of 0-20 cmH(2)O and subsequent deflation, each lasting for similar to20 s. Zrs was averaged for 0.125 s and fitted by a model featuring airway resistance ( Raw) and inertance, and tissue damping and elastance ( H). Lower airway conductance (Glaw) was linearly related to volume above functional residual capacity (V) between 0 and 75 - 95% maximum V, with a mean slope of dGlaw/dV = 13.6 +/- 4.6 cmH(2)O(-1) . s(-1). The interdependence of Raw and H was characterized by two distinct and closely linear relationships for the low- and high-volume regions, separated at similar to 40% maximum V. Comparison of Raw with the highest-frequency resistance of the total respiratory system revealed a marked volume-dependent contribution of tissue resistance to total respiratory system resistance, resulting in the overestimation of Raw by 19 +/- 8 and 163 +/- 40% at functional residual capacity and total lung capacity, respectively, whereas the lowest frequency reactance was proportional to H; these findings indicate that single- frequency resistance values may become inappropriate as surrogates of Raw when tissue impedance is changing.

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DO - 10.1152/japplphysiol.00104.2003

M3 - Article

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SP - 1695

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JF - Journal of applied physiology (Bethesda, Md. : 1985)

SN - 1522-1601

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