Tracheobronchitis in ulcerative colitis: A case report of therapeutic response with infliximab and review of the literature

Lisa Horgan, Siobhain Mulrennan, Lloyd D'Orsogna, Andrew McLean-Tooke

Research output: Contribution to journalReview article

Abstract

Background: The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infliximab are demonstrated. Case presentation: We report the case of a 39-year old woman who presented with a chronic productive cough on a distant background of surgically managed ulcerative colitis (UC). Our patient failed to achieve a satisfactory clinical improvement despite treatment with high dose inhaled corticosteroids, oral corticosteroids and azathioprine. Infliximab therapy was commenced and was demonstrated to achieve macroscopic and symptomatic remission of disease. Conclusions: We present the first case report documenting the benefits of infliximab in UC-related tracheobronchitis.

Original languageEnglish
Article number171
JournalBMC Gastroenterology
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Nov 2019

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Ulcerative Colitis
Adrenal Cortex Hormones
Azathioprine
Therapeutics
Cough
Infliximab

Cite this

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abstract = "Background: The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infliximab are demonstrated. Case presentation: We report the case of a 39-year old woman who presented with a chronic productive cough on a distant background of surgically managed ulcerative colitis (UC). Our patient failed to achieve a satisfactory clinical improvement despite treatment with high dose inhaled corticosteroids, oral corticosteroids and azathioprine. Infliximab therapy was commenced and was demonstrated to achieve macroscopic and symptomatic remission of disease. Conclusions: We present the first case report documenting the benefits of infliximab in UC-related tracheobronchitis.",
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Tracheobronchitis in ulcerative colitis : A case report of therapeutic response with infliximab and review of the literature. / Horgan, Lisa; Mulrennan, Siobhain; D'Orsogna, Lloyd; McLean-Tooke, Andrew.

In: BMC Gastroenterology, Vol. 19, No. 1, 171, 01.11.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Tracheobronchitis in ulcerative colitis

T2 - A case report of therapeutic response with infliximab and review of the literature

AU - Horgan, Lisa

AU - Mulrennan, Siobhain

AU - D'Orsogna, Lloyd

AU - McLean-Tooke, Andrew

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infliximab are demonstrated. Case presentation: We report the case of a 39-year old woman who presented with a chronic productive cough on a distant background of surgically managed ulcerative colitis (UC). Our patient failed to achieve a satisfactory clinical improvement despite treatment with high dose inhaled corticosteroids, oral corticosteroids and azathioprine. Infliximab therapy was commenced and was demonstrated to achieve macroscopic and symptomatic remission of disease. Conclusions: We present the first case report documenting the benefits of infliximab in UC-related tracheobronchitis.

AB - Background: The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infliximab are demonstrated. Case presentation: We report the case of a 39-year old woman who presented with a chronic productive cough on a distant background of surgically managed ulcerative colitis (UC). Our patient failed to achieve a satisfactory clinical improvement despite treatment with high dose inhaled corticosteroids, oral corticosteroids and azathioprine. Infliximab therapy was commenced and was demonstrated to achieve macroscopic and symptomatic remission of disease. Conclusions: We present the first case report documenting the benefits of infliximab in UC-related tracheobronchitis.

KW - Inflammatory bowel disease

KW - Tracheobronchitis

KW - Ulcerative colitis

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U2 - 10.1186/s12876-019-1091-0

DO - 10.1186/s12876-019-1091-0

M3 - Review article

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JO - BMC Gastroenterology

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