Introduction/Aim: Pleural effusions are common and contain abundant nutrients and growth factors. Trace elements are increasingly recognized for their potent and diverse range of biological roles. For example, we recently found that manganese is important in Streptococcus pneumoniae proliferation in empyema. Trace elements have rarely been investigated in pleural diseases. This study aimed to determine the presence and concentrations of trace elements in human pleural effusions. Methods: We analysed 119 pleural fluid samples which included 71 malignant (39 mesothelioma), 16 parapneumonic (including empyema), 14 heart failure and 16 other miscellaneous benign effusions. Iron (Fe), manganese (Mn), copper (Cu), zinc (Zn), cobalt (Co) and molybdenum (Mo) were assayed by a NATA accredited hospital laboratory (PathWest, WA). Clinical diagnoses of the effusions were verified by a respiratory specialist. Results: All trace elements were detected in the pleural effusions: median (IQR) levels of Fe 8.02 (3.96-16.80) umol/L; Mn 10.71 (5.64-18.04) nmol/L; Cu 9.05 (5.98-14.77) umol/L; Zn 5.84 (3.26-8.67) umol/L; Co 1.58 (1.05-2.63) nmol/L and Mo 7.91 (5.38-15.82) nmol/L. Strong (Spearman) correlations were found between Fe and Mn as well as Znand Cu levels (0.742 and 0.745, both p
|Publication status||Published - Apr 2018|
|Event||The Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science - Adelaide Convention and Exhibition Centre, Adelaide, Australia|
Duration: 23 Mar 2018 → 27 Mar 2018
Conference number: 2018
|Conference||The Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science|
|Period||23/03/18 → 27/03/18|
Popowicz, N. D., Fitzgerald, D., Joseph, J., Lim, E. M., Cheah, H. M., Butcher, S., Creaney, J., & Lee, Y. C. G. (2018). Trace element concentrations in human pleural effusions. 114. Abstract from The Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Adelaide, Australia.