Towards a universal molecular microbiological test

Richard J.N. Allcock, Amy V. Jennison, David Warrilow

Research output: Contribution to journalReview articlepeer-review

15 Citations (Web of Science)


The standard paradigm for microbiological testing is dependent on the presentation of a patient to a clinician. Tests are then requested based on differential diagnoses using the patient's symptoms as a guide. The era of high-throughput genomic methods has the potential to replace this model for the first time with what could be referred to as "hypothesis-free testing." This approach utilizes one of a variety of methodologies to obtain a sequence from potentially any nucleic acid in a clinical sample, without prior knowledge of its content. We discuss the advantages of such an approach and the challenges in making this a reality.

Original languageEnglish
Pages (from-to)3175-3182
Number of pages8
JournalJournal of Clinical Microbiology
Issue number11
Publication statusPublished - 1 Nov 2017


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