Abstract
The first approaches to the 10'-anthronyl-2-anthraquinone skeleton have been devised, allowing two syntheses of the marine natural product albopunctatone. Both routes involve regioselective addition of a nucleophilic masked anthraquinone to a protected chrysazin derivative; the best affords albopunctatone in five steps and 35% overall yield. Albopunctatone exhibits potent inhibitory activity against Plasmodium falciparum and negligible toxicity to a range of other microbial pathogens and mammalian cells.
Original language | English |
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Pages (from-to) | 5519-5523 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 21 |
Issue number | 14 |
DOIs | |
Publication status | Published - 9 Jul 2019 |