Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.

Original languageEnglish
Pages (from-to)3902-3915.e8
JournalCell Reports
Volume29
Issue number12
DOIs
Publication statusPublished - 17 Dec 2019

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