@article{df7ac88f3dfe4086a0e401ab3bc4139d,
title = "Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation",
abstract = "Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.",
keywords = "activation induced deaminase, chromatin loop extrusion, chromatin structure, somatic hypermutation, topologically associated domain, transcription factor",
author = "Filip Senigl and Yaakov Maman and Dinesh, {Ravi K.} and Jukka Alinikula and Seth, {Rashu B.} and Lubomira Pecnova and Omer, {Arina D.} and Rao, {Suhas S.P.} and David Weisz and Buerstedde, {Jean Marie} and Aiden, {Erez Lieberman} and Rafael Casellas and Jiri Hejnar and Schatz, {David G.}",
year = "2019",
month = dec,
day = "17",
doi = "10.1016/j.celrep.2019.11.039",
language = "English",
volume = "29",
pages = "3902--3915.e8",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",
}