TOPLESS co-repressor interactions and their evolutionary conservation in plants

Barry Causier, James Lloyd, Laura Stevens, Brendan Davies

Research output: Contribution to journalArticle

29 Citations (Scopus)


Large-scale protein-protein interaction studies recently demonstrated that the Arabidopsis TPL/TPR family of transcriptional co-repressors is involved in a broad range of developmental processes. TPL/TPRs predominantly interact with transcription factors that contain repression domain (RD) sequences. Interestingly, RDs reported in the literature are quite diverse in sequence, yet TPL/TPRs interact with proteins containing all of the known motifs. These data lead us to conclude that the TPL/TPRs act as general repressors of gene transcription in plants. To investigate this further, we examined interactions between TPL/TPR proteins encoded by the moss Physcomitrella patens genome and components of the auxin signaling pathway. As in Arabidopsis, moss TPL proteins interact with AUX/IAA and ARF proteins, suggesting that they act in both forms of ARF-mediated transcriptional repression. These data suggest that the involvement of TPL in auxin signaling has been conserved across evolution, since mosses and angiosperms diverged approximately 450 million years ago.

Original languageEnglish
Pages (from-to)325-8
Number of pages4
JournalPlant signaling & behavior
Issue number3
Publication statusPublished - Mar 2012
Externally publishedYes

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