To respond or not to respond? Exploring and exploiting dynamic mechanisms underlying cancer immunotherapy

Research output: ThesisDoctoral Thesis

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Abstract

Cancer immunotherapy using antibodies that target immune checkpoints has delivered outstanding results. However, responses only occur in a subset of patients. A lack of understanding what biological processes determine an effective outcome has hindered the identification of reliable biomarkers, as well as the development of rational combination treatments. In this thesis I dissect the molecular events associated with responsiveness to immune checkpoint blockade, in order to identify predictive biomarkers and therapeutic targets to manoeuvre the immune response in the direction of tumour regression, to improve response rates.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lesterhuis, Willem, Supervisor
  • Lake, Richard, Supervisor
  • Nowak, Anna, Supervisor
Thesis sponsors
Award date13 Jun 2019
DOIs
Publication statusUnpublished - 2019

Embargo information

  • Embargoed from 20/06/2019 to 01/06/2021. Made publicly available on 01/06/2021.

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