TY - JOUR
T1 - Timing of prophylactic antibiotic administration in the uninfected laboring gravida: A randomized clinical trial
AU - Thigpen, B.D.
AU - Hood, W.A.
AU - Chauhan, S.
AU - Bufkin, L.
AU - Bofill, J.
AU - Magann, Pat
AU - Morrison, J.C.
PY - 2005
Y1 - 2005
N2 - Objective: The purpose of this prospective study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal/neonatal infectious morbidity.Study design: In this double-blind placebo-controlled trial, cefazolin was given at skin incision (group A) or at cord clamping (group B). Patients were eligible for the trial if they had labored and required a cesarean delivery.Results: Over a 30-month period 303 patients with singleton pregnancies entered the trial; 153-group A, 149-group B. Demographics, indication for cesarean delivery (P = .54), and operative time (P = .999), as well as rates of endometritis (RR 0.67, 95% CI 0.42-1.07), wound infection (RR 0.84, 95% CI 0.45-1.55), neonatal sepis (RR 1.28, 95% Cl 0.91-1.79), and NICU admissions (RR 1.28, 95% CI 0.91-1.79) were similar between the 2 groups.Conclusion: There was no difference in maternal infectious morbidity whether antibiotics were given before skin incision or at cord clamping. (c) 2005 Elsevier Inc. All rights reserved.
AB - Objective: The purpose of this prospective study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal/neonatal infectious morbidity.Study design: In this double-blind placebo-controlled trial, cefazolin was given at skin incision (group A) or at cord clamping (group B). Patients were eligible for the trial if they had labored and required a cesarean delivery.Results: Over a 30-month period 303 patients with singleton pregnancies entered the trial; 153-group A, 149-group B. Demographics, indication for cesarean delivery (P = .54), and operative time (P = .999), as well as rates of endometritis (RR 0.67, 95% CI 0.42-1.07), wound infection (RR 0.84, 95% CI 0.45-1.55), neonatal sepis (RR 1.28, 95% Cl 0.91-1.79), and NICU admissions (RR 1.28, 95% CI 0.91-1.79) were similar between the 2 groups.Conclusion: There was no difference in maternal infectious morbidity whether antibiotics were given before skin incision or at cord clamping. (c) 2005 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.ajog.2004.12.063
DO - 10.1016/j.ajog.2004.12.063
M3 - Article
C2 - 15970833
VL - 192
SP - 1864
EP - 1871
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
SN - 0002-9378
ER -