Time for radical changes in brain stem nomenclature—Applying the lessons from developmental gene patterns

Charles Watson, Caitlin Bartholomaeus, Luis Puelles

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The traditional subdivision of the brain stem into midbrain, pons, and medulla oblongata is based purely on the external appearance of the human brain stem. There is an urgent need to update the names of brain stem structures to be consistent with the discovery of rhomobomeric segmentation based on gene expression. The most important mistakes are the belief that the pons occupies the upper half of the hindbrain, the failure to recognize the isthmus as the first segment of the hindbrain, and the mistaken inclusion of diencephalic structures in the midbrain. The new nomenclature will apply to all mammals. This essay recommends a new brain stem nomenclature based on developmental gene expression, progeny analysis, and fate mapping. In addition, we have made comment on the names given to a number of internal brain stem structures and have offered alternatives where necessary.

Original languageEnglish
Article number10
JournalFrontiers in Neuroanatomy
Volume13
DOIs
Publication statusPublished - 18 Feb 2019

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Developmental Genes
Brain Stem
Rhombencephalon
Pons
Mesencephalon
Terminology
Names
Gene Expression
Medulla Oblongata
Mammals

Cite this

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Time for radical changes in brain stem nomenclature—Applying the lessons from developmental gene patterns. / Watson, Charles; Bartholomaeus, Caitlin; Puelles, Luis.

In: Frontiers in Neuroanatomy, Vol. 13, 10, 18.02.2019.

Research output: Contribution to journalArticle

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