Projects per year
Abstract
Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tumor RNA sequencing data in the context of treatment with ICB in murine models of AB1 mesothelioma and Renca renal cell cancer. We sequenced 144 bulk RNAseq samples from these two cancer types across 4 time points prior and after treatment with ICB. We also performed single-cell sequencing on 12 samples of AB1 and Renca tumors an hour before ICB administration. Our samples were equally distributed between responders and non-responders to treatment. Additionally, we sequenced AB1-HA mesothelioma tumors treated with two sample dissociation protocols to assess the impact of these protocols on the quality transcriptional information in our samples. These datasets provide time-course information to transcriptionally characterize the ICB response and provide detailed information at the single-cell level of the early tumor microenvironment prior to ICB therapy.
Original language | English |
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Article number | 448 |
Journal | Scientific Data |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 2024 |
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Dive into the research topics of 'Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy'. Together they form a unique fingerprint.Projects
- 3 Finished
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Systems Biology of Human Disease
Forrest, A. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/23
Project: Research
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National Centre for Asbestos Related Diseases
Robinson, B. (Investigator 01), Creaney, J. (Investigator 02), Lake, R. (Investigator 03), Nowak, A. (Investigator 04), Musk, A. (Investigator 05), Lesterhuis, W. (Investigator 06) & Lee, G. (Investigator 07)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/20
Project: Research
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Resetting the tipping point: Converting immune checkpoint non-responders into responders
Lesterhuis, W. (Investigator 01), Lake, R. (Investigator 02), Bosco, A. (Investigator 03), Dudley, J. (Investigator 04) & Nowak, A. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/16 → 30/11/19
Project: Research