Thyrotropin Receptor Purification

Peter J. Leedman; Leonard C. Harrison

doi:10.1007/978-1-4612-0461-9_12

Thyrotropin Receptor Purification

Research output: Chapter in Book/Conference paper › Chapter › peer-review

Abstract

Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of adenylate cyclase, production of cyclic AMP and activation of protein kinases, stimulation of phospholipid turnover and mobilization of intracellular calcium) that are presumed to mediate the bioeffects of TSH, i.e., iodothyronine hormone synthesis and release and thyroid growth (for review, see Field, 1986).

Original language	English
Title of host publication	Receptor Purification
Editors	Gerald Litwack
Publisher	Humana Press Inc.
Pages	249-268
Volume	1
ISBN (Electronic)	978-1-4612-0461-9
ISBN (Print)	978-0-89603-167-8, 978-1-4612-6771-3
DOIs	https://doi.org/10.1007/978-1-4612-0461-9_12
Publication status	Published - 1990
Externally published	Yes

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10.1007/978-1-4612-0461-9_12

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@inbook{ed11a945b66f4336a1ecbbe784991668,

title = "Thyrotropin Receptor Purification",

abstract = "Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of adenylate cyclase, production of cyclic AMP and activation of protein kinases, stimulation of phospholipid turnover and mobilization of intracellular calcium) that are presumed to mediate the bioeffects of TSH, i.e., iodothyronine hormone synthesis and release and thyroid growth (for review, see Field, 1986).",

author = "Leedman, {Peter J.} and Harrison, {Leonard C.}",

year = "1990",

doi = "10.1007/978-1-4612-0461-9_12",

language = "English",

isbn = "978-0-89603-167-8",

volume = "1",

pages = "249--268",

editor = "Litwack, {Gerald }",

booktitle = "Receptor Purification",

publisher = "Humana Press Inc.",

address = "United States",

}

TY - CHAP

T1 - Thyrotropin Receptor Purification

AU - Leedman, Peter J.

AU - Harrison, Leonard C.

PY - 1990

Y1 - 1990

N2 - Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of adenylate cyclase, production of cyclic AMP and activation of protein kinases, stimulation of phospholipid turnover and mobilization of intracellular calcium) that are presumed to mediate the bioeffects of TSH, i.e., iodothyronine hormone synthesis and release and thyroid growth (for review, see Field, 1986).

AB - Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of adenylate cyclase, production of cyclic AMP and activation of protein kinases, stimulation of phospholipid turnover and mobilization of intracellular calcium) that are presumed to mediate the bioeffects of TSH, i.e., iodothyronine hormone synthesis and release and thyroid growth (for review, see Field, 1986).

U2 - 10.1007/978-1-4612-0461-9_12

DO - 10.1007/978-1-4612-0461-9_12

M3 - Chapter

SN - 978-0-89603-167-8

SN - 978-1-4612-6771-3

VL - 1

SP - 249

EP - 268

BT - Receptor Purification

A2 - Litwack, Gerald

PB - Humana Press Inc.

ER -

Thyrotropin Receptor Purification

Abstract

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