Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care

C.L. Paul; C.R. Levi; C.A. D'Este; M.W. Parsons; C.F. Bladin; R.I. Lindley; J.R. Attia; F.A. Henskens; E.E. Lalor; M. Longworth; S. Middleton; A. Ryan; E. Kerr; R.W. Sanson- Fisher; C.S. Anderson; I. Bruce; H.A. Buchan; C. Burdusel; E.G. Butler; G. Cadigan; Z. Campbell; T.E. Coles; A.J. Corbett; S. Day; S.M. Denisenko; J. Dennett; H.M. Dewey; G.A. Donnan; M.J. Doughty; M.K. Evans; F. Gearon; R. Geraghty; R.P. Gerraty; S. Gounden; A. Grady; R.S. Grimley; J.M. Grimshaw; Graeme Hankey; K.M. Hill; K.G. Hoffman; S.D. Huckson; J.T. Hughes; A. Jayakody; B. Jenkins; M.R. Jude; M. Kanard; M. Kinchington; M.F. Krause; S. Kuhle; P. Laird; A. Lee; S. Levy; K. Longworth; B. Macdonald; E. Mackey; K. Mandaleson; K. Mohr; S.T. Moore; K. Morris; E.M. O'Brien; B. Paddock; K. Parrey; R. Peake; M.R.P. Pollack; C.J.S. Price; S.K. Rose; J. Rupasinghe; F.S. Ryan; A.M. Searles; R. Smits; M. Stevenson; S. Taneja; Z. Terpening; N. Teasdale; J.D.G. Watson; A. Wilson; Y. Weiner; T. Wijeratne; N. Wolfe

doi:10.1186/1748-5908-9-38

Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care

C.L. Paul, C.R. Levi, C.A. D'Este, M.W. Parsons, C.F. Bladin, R.I. Lindley, J.R. Attia, F.A. Henskens, E.E. Lalor, M. Longworth, S. Middleton, A. Ryan, E. Kerr, R.W. Sanson- Fisher, C.S. Anderson, I. Bruce, H.A. Buchan, C. Burdusel, E.G. Butler, G. CadiganZ. Campbell, T.E. Coles, A.J. Corbett, S. Day, S.M. Denisenko, J. Dennett, H.M. Dewey, G.A. Donnan, M.J. Doughty, M.K. Evans, F. Gearon, R. Geraghty, R.P. Gerraty, S. Gounden, A. Grady, R.S. Grimley, J.M. Grimshaw, Graeme Hankey, K.M. Hill, K.G. Hoffman, S.D. Huckson, J.T. Hughes, A. Jayakody, B. Jenkins, M.R. Jude, M. Kanard, M. Kinchington, M.F. Krause, S. Kuhle, P. Laird, A. Lee, S. Levy, K. Longworth, B. Macdonald, E. Mackey, K. Mandaleson, K. Mohr, S.T. Moore, K. Morris, E.M. O'Brien, B. Paddock, K. Parrey, R. Peake, M.R.P. Pollack, C.J.S. Price, S.K. Rose, J. Rupasinghe, F.S. Ryan, A.M. Searles, R. Smits, M. Stevenson, S. Taneja, Z. Terpening, N. Teasdale, J.D.G. Watson, A. Wilson, Y. Weiner, T. Wijeratne, N. Wolfe

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS

Original language	English
Pages (from-to)	1-10
Journal	Implementation Science
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1748-5908-9-38
Publication status	Published - 2014

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Paul, C. L., Levi, C. R., D'Este, C. A., Parsons, M. W., Bladin, C. F., Lindley, R. I., Attia, J. R., Henskens, F. A., Lalor, E. E., Longworth, M., Middleton, S., Ryan, A., Kerr, E., Sanson- Fisher, R. W., Anderson, C. S., Bruce, I., Buchan, H. A., Burdusel, C., Butler, E. G., ... Wolfe, N. (2014). Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care. Implementation Science, 9(1), 1-10. https://doi.org/10.1186/1748-5908-9-38

@article{3ae206f7ad7649a4875130f1c2e2abe5,

title = "Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care",

abstract = "Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS",

author = "C.L. Paul and C.R. Levi and C.A. D'Este and M.W. Parsons and C.F. Bladin and R.I. Lindley and J.R. Attia and F.A. Henskens and E.E. Lalor and M. Longworth and S. Middleton and A. Ryan and E. Kerr and {Sanson- Fisher}, R.W. and C.S. Anderson and I. Bruce and H.A. Buchan and C. Burdusel and E.G. Butler and G. Cadigan and Z. Campbell and T.E. Coles and A.J. Corbett and S. Day and S.M. Denisenko and J. Dennett and H.M. Dewey and G.A. Donnan and M.J. Doughty and M.K. Evans and F. Gearon and R. Geraghty and R.P. Gerraty and S. Gounden and A. Grady and R.S. Grimley and J.M. Grimshaw and Graeme Hankey and K.M. Hill and K.G. Hoffman and S.D. Huckson and J.T. Hughes and A. Jayakody and B. Jenkins and M.R. Jude and M. Kanard and M. Kinchington and M.F. Krause and S. Kuhle and P. Laird and A. Lee and S. Levy and K. Longworth and B. Macdonald and E. Mackey and K. Mandaleson and K. Mohr and S.T. Moore and K. Morris and E.M. O'Brien and B. Paddock and K. Parrey and R. Peake and M.R.P. Pollack and C.J.S. Price and S.K. Rose and J. Rupasinghe and F.S. Ryan and A.M. Searles and R. Smits and M. Stevenson and S. Taneja and Z. Terpening and N. Teasdale and J.D.G. Watson and A. Wilson and Y. Weiner and T. Wijeratne and N. Wolfe",

year = "2014",

doi = "10.1186/1748-5908-9-38",

language = "English",

volume = "9",

pages = "1--10",

journal = "Implementation Science",

issn = "1748-5908",

publisher = "BioMed Central",

number = "1",

}

Paul, CL, Levi, CR, D'Este, CA, Parsons, MW, Bladin, CF, Lindley, RI, Attia, JR, Henskens, FA, Lalor, EE, Longworth, M, Middleton, S, Ryan, A, Kerr, E, Sanson- Fisher, RW, Anderson, CS, Bruce, I, Buchan, HA, Burdusel, C, Butler, EG, Cadigan, G, Campbell, Z, Coles, TE, Corbett, AJ, Day, S, Denisenko, SM, Dennett, J, Dewey, HM, Donnan, GA, Doughty, MJ, Evans, MK, Gearon, F, Geraghty, R, Gerraty, RP, Gounden, S, Grady, A, Grimley, RS, Grimshaw, JM, Hankey, G, Hill, KM, Hoffman, KG, Huckson, SD, Hughes, JT, Jayakody, A, Jenkins, B, Jude, MR, Kanard, M, Kinchington, M, Krause, MF, Kuhle, S, Laird, P, Lee, A, Levy, S, Longworth, K, Macdonald, B, Mackey, E, Mandaleson, K, Mohr, K, Moore, ST, Morris, K, O'Brien, EM, Paddock, B, Parrey, K, Peake, R, Pollack, MRP, Price, CJS, Rose, SK, Rupasinghe, J, Ryan, FS, Searles, AM, Smits, R, Stevenson, M, Taneja, S, Terpening, Z, Teasdale, N, Watson, JDG, Wilson, A, Weiner, Y, Wijeratne, T & Wolfe, N 2014, 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care', Implementation Science, vol. 9, no. 1, pp. 1-10. https://doi.org/10.1186/1748-5908-9-38

Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care. / Paul, C.L.; Levi, C.R.; D'Este, C.A. et al.
In: Implementation Science, Vol. 9, No. 1, 2014, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care

AU - Paul, C.L.

AU - Levi, C.R.

AU - D'Este, C.A.

AU - Parsons, M.W.

AU - Bladin, C.F.

AU - Lindley, R.I.

AU - Attia, J.R.

AU - Henskens, F.A.

AU - Lalor, E.E.

AU - Longworth, M.

AU - Middleton, S.

AU - Ryan, A.

AU - Kerr, E.

AU - Sanson- Fisher, R.W.

AU - Anderson, C.S.

AU - Bruce, I.

AU - Buchan, H.A.

AU - Burdusel, C.

AU - Butler, E.G.

AU - Cadigan, G.

AU - Campbell, Z.

AU - Coles, T.E.

AU - Corbett, A.J.

AU - Day, S.

AU - Denisenko, S.M.

AU - Dennett, J.

AU - Dewey, H.M.

AU - Donnan, G.A.

AU - Doughty, M.J.

AU - Evans, M.K.

AU - Gearon, F.

AU - Geraghty, R.

AU - Gerraty, R.P.

AU - Gounden, S.

AU - Grady, A.

AU - Grimley, R.S.

AU - Grimshaw, J.M.

AU - Hankey, Graeme

AU - Hill, K.M.

AU - Hoffman, K.G.

AU - Huckson, S.D.

AU - Hughes, J.T.

AU - Jayakody, A.

AU - Jenkins, B.

AU - Jude, M.R.

AU - Kanard, M.

AU - Kinchington, M.

AU - Krause, M.F.

AU - Kuhle, S.

AU - Laird, P.

AU - Lee, A.

AU - Levy, S.

AU - Longworth, K.

AU - Macdonald, B.

AU - Mackey, E.

AU - Mandaleson, K.

AU - Mohr, K.

AU - Moore, S.T.

AU - Morris, K.

AU - O'Brien, E.M.

AU - Paddock, B.

AU - Parrey, K.

AU - Peake, R.

AU - Pollack, M.R.P.

AU - Price, C.J.S.

AU - Rose, S.K.

AU - Rupasinghe, J.

AU - Ryan, F.S.

AU - Searles, A.M.

AU - Smits, R.

AU - Stevenson, M.

AU - Taneja, S.

AU - Terpening, Z.

AU - Teasdale, N.

AU - Watson, J.D.G.

AU - Wilson, A.

AU - Weiner, Y.

AU - Wijeratne, T.

AU - Wolfe, N.

PY - 2014

Y1 - 2014

N2 - Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS

AB - Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS

U2 - 10.1186/1748-5908-9-38

DO - 10.1186/1748-5908-9-38

M3 - Article

C2 - 24666591

SN - 1748-5908

VL - 9

SP - 1

EP - 10

JO - Implementation Science

JF - Implementation Science

IS - 1

ER -