Three-dimensional visualisation of the feto-placental vasculature in humans and rodents

J. L. James, Y. Tongpob, V. Srinivasan, R. C. Crew, N. Bappoo, B. Doyle, D. Gerneke, A. R. Clark, C. S. Wyrwoll

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Adequate development of the feto-placental circulation is critical for placental exchange function and healthy fetal growth. Understanding the structure of this circulation and how it informs fetal outcomes is important both in the human placenta, and the rodent, a purported comparative experimental model. Vascular casting and micro-CT imaging approaches enable detailed quantification of the complex vascular relationships in the feto-circulation, and provide detailed data to parameterise in silico models. Here, to assist researchers to apply these technically challenging methods we provide detailed approaches to cast and image; 1) human placentas at the cotyledon-level, and 2) whole rodent placentas.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalPlacenta
Volume114
DOIs
Publication statusPublished - Oct 2021

Fingerprint

Dive into the research topics of 'Three-dimensional visualisation of the feto-placental vasculature in humans and rodents'. Together they form a unique fingerprint.

Cite this