Three-dimensional optical coherence micro-elastography of skeletal muscle tissue

Lixin Chin, Brendan Kennedy, Kelsey Kennedy, Philip Wijesinghe, Gavin Pinniger, Jessica Terrill, Robert Mclaughlin, David Sampson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In many muscle pathologies, impairment of skeletal muscle function is closely linked to changes in the mechanical properties of the muscle constituents. Optical coherence micro-elastography (OCME) uses optical coherence tomography (OCT) imaging of tissue under a quasi-static, compressive mechanical load to map variations in tissue mechanical properties on the micro-scale. We present the first study of OCME on skeletal muscle tissue. We show that this technique can resolve features of muscle tissue including fibers, fascicles and tendon, and can also detect necrotic lesions in skeletal muscle from the mdx mouse model of Duchenne muscular dystrophy. In many instances, OCME provides better or additional contrast complementary to that provided by OCT. These results suggest that OCME could provide new understanding and opportunity for assessment of skeletal muscle pathologies.
© 2014 Optical Society of America

Original languageEnglish
Pages (from-to)3090-3102
JournalBiomedical Optics Express
Volume5
Issue number9
Early online date22 Aug 2014
DOIs
Publication statusPublished - 1 Sep 2014

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