Therapeutic Potential of Pomegranate in Metabolic Disorders

Maryam Akaberi, Zahra Boghrati, Amirhossein Sahebkar, Seyed Ahmad Emami

Research output: Chapter in Book/Conference paperChapterpeer-review

1 Citation (Scopus)


Metabolic syndrome and associated disorders have become one of the major challenging health problems over the last decades. Considerable attention has been paid to natural products and herbal medicines for the management of metabolic disorders in recent years. Many studies have investigated the therapeutic effects of different parts (arils, peels, seeds, and flowers) of pomegranate (Punica granatum L.) for the prevention and treatment of this syndrome. This study aims to provide an updated review on the in vitro and in vivo studies as well as clinical trials investigating the effects of pomegranate and its active compounds on different components of metabolic problems such as hyperglycemia, hyperlipidemia, hypertension, as well as obesity over the last two decades. Besides, the key mechanisms by which pomegranate affects these pathogenic conditions are also discussed. The studies show that although pomegranate has promising beneficial effects on diabetes, hypertension, hyperlipidemia, and obesity in various cellular, animal, and clinical models of studies, there are some conflicting results, particularly for hyperglycemic conditions. The main mechanisms include influencing oxidative stress and anti-inflammatory responses. Overall, pomegranate seems to have positive effects on the pathogenic conditions of metabolic syndrome according to the reviewed studies. Although pomegranate is not suggested as the first line of therapy or monotherapy, it could be only used as an adjunctive therapy. Nevertheless, further large and long-term clinical studies are still required.

Original languageEnglish
Title of host publicationNatural Products and Human Diseases
Subtitle of host publicationPharmacology, Molecular Targets, and Therapeutic Benefits
EditorsAmirhossein Sahebkar, Thozhukat Sathyapalan
Place of PublicationSwitzerland
PublisherSpringer Heidelberg
Number of pages20
ISBN (Electronic)978-3-030-73234-9
ISBN (Print)978-3-030-73233-2
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


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