Therapeutic potential and outlook of alternative medicine for osteoporosis

Tao Wang, Qian Liu, William Tjhioe, Jinmin Zhao, Aiping Lu, Ge Zhang, Ren Xiang Tan, Mengyu Zhou, Jiake Xu, Hao Tian Feng

    Research output: Contribution to journalReview article

    14 Citations (Scopus)

    Abstract

    Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.

    Original languageEnglish
    Pages (from-to)1051-1068
    Number of pages18
    JournalCurrent Drug Targets
    Volume18
    Issue number9
    DOIs
    Publication statusPublished - 1 Jul 2017

    Fingerprint

    Bioelectric potentials
    Complementary Therapies
    Osteoporosis
    Medicine
    Bone
    Bone Density Conservation Agents
    Bone Density
    Therapeutics
    Phytoestrogens
    Diphosphonates
    Nutrition
    Parathyroid Hormone
    Phytotherapy
    Bone and Bones
    Postmenopausal Osteoporosis
    Herbal Medicine
    Metabolic Bone Diseases
    Estrogens
    Bone Diseases
    Anti-Inflammatory Agents

    Cite this

    Wang, T., Liu, Q., Tjhioe, W., Zhao, J., Lu, A., Zhang, G., ... Feng, H. T. (2017). Therapeutic potential and outlook of alternative medicine for osteoporosis. Current Drug Targets, 18(9), 1051-1068. https://doi.org/10.2174/1389450118666170321105425
    Wang, Tao ; Liu, Qian ; Tjhioe, William ; Zhao, Jinmin ; Lu, Aiping ; Zhang, Ge ; Tan, Ren Xiang ; Zhou, Mengyu ; Xu, Jiake ; Feng, Hao Tian. / Therapeutic potential and outlook of alternative medicine for osteoporosis. In: Current Drug Targets. 2017 ; Vol. 18, No. 9. pp. 1051-1068.
    @article{ebb950e20c974181997bd604b23afb3b,
    title = "Therapeutic potential and outlook of alternative medicine for osteoporosis",
    abstract = "Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.",
    keywords = "Herbal medicine, Natural compounds, Osteoblast, Osteoclast, Osteoporosis, Postmenopausal osteoporosis",
    author = "Tao Wang and Qian Liu and William Tjhioe and Jinmin Zhao and Aiping Lu and Ge Zhang and Tan, {Ren Xiang} and Mengyu Zhou and Jiake Xu and Feng, {Hao Tian}",
    year = "2017",
    month = "7",
    day = "1",
    doi = "10.2174/1389450118666170321105425",
    language = "English",
    volume = "18",
    pages = "1051--1068",
    journal = "Current Drug Targets",
    issn = "1389-4501",
    publisher = "BENTHAM SCIENCE PUBL LTD",
    number = "9",

    }

    Wang, T, Liu, Q, Tjhioe, W, Zhao, J, Lu, A, Zhang, G, Tan, RX, Zhou, M, Xu, J & Feng, HT 2017, 'Therapeutic potential and outlook of alternative medicine for osteoporosis' Current Drug Targets, vol. 18, no. 9, pp. 1051-1068. https://doi.org/10.2174/1389450118666170321105425

    Therapeutic potential and outlook of alternative medicine for osteoporosis. / Wang, Tao; Liu, Qian; Tjhioe, William; Zhao, Jinmin; Lu, Aiping; Zhang, Ge; Tan, Ren Xiang; Zhou, Mengyu; Xu, Jiake; Feng, Hao Tian.

    In: Current Drug Targets, Vol. 18, No. 9, 01.07.2017, p. 1051-1068.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Therapeutic potential and outlook of alternative medicine for osteoporosis

    AU - Wang, Tao

    AU - Liu, Qian

    AU - Tjhioe, William

    AU - Zhao, Jinmin

    AU - Lu, Aiping

    AU - Zhang, Ge

    AU - Tan, Ren Xiang

    AU - Zhou, Mengyu

    AU - Xu, Jiake

    AU - Feng, Hao Tian

    PY - 2017/7/1

    Y1 - 2017/7/1

    N2 - Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.

    AB - Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.

    KW - Herbal medicine

    KW - Natural compounds

    KW - Osteoblast

    KW - Osteoclast

    KW - Osteoporosis

    KW - Postmenopausal osteoporosis

    UR - http://www.scopus.com/inward/record.url?scp=85022177286&partnerID=8YFLogxK

    U2 - 10.2174/1389450118666170321105425

    DO - 10.2174/1389450118666170321105425

    M3 - Review article

    VL - 18

    SP - 1051

    EP - 1068

    JO - Current Drug Targets

    JF - Current Drug Targets

    SN - 1389-4501

    IS - 9

    ER -