TY - JOUR
T1 - The worldwide antibiotic resistance and prescribing in european children (ARPEC) point prevalence survey
T2 - Developing hospital-quality indicators of antibiotic prescribing for children
AU - ARPEC project group
AU - Versporten, Ann
AU - Bielicki, Julia
AU - Drapier, Nico
AU - Sharland, Mike
AU - Goossens, Hermanon
AU - Calle, Graciela Maria
AU - Clark, Julia
AU - Cooper, Celia
AU - Blyth, Christopher C.
AU - Francis, Joshua Reginald
AU - Alsalman, Jameela
AU - Jansens, Hilde
AU - Mahieu, Ludo
AU - Van Rossom, Paul
AU - Vandewal, Wouter
AU - Lepage, Philippe
AU - Blumental, Sophie
AU - Briquet, Caroline
AU - Robbrecht, Dirk
AU - Maton, Pierre
AU - Gabriels, Patrick
AU - Rubic, Zana
AU - Kovacevic, Tanja
AU - Nielsen, Jens Peter
AU - Petersen, Jes Reinholdt
AU - Poorisrisak, Porntiva
AU - Jensen, Lise Heilmann
AU - Laan, Mari
AU - Tamm, Eda
AU - Matsinen, Maire
AU - Rummukainen, Maija Liisa
AU - Gajdos, Vincent
AU - Olivier, Romain
AU - Le Maréchal, Flore
AU - Martinot, Alain
AU - Prot-Labarthe, Sonia
AU - Lorrot, Mathie
AU - Orbach, Daniel
AU - Pagava, Karaman
AU - Hufnagel, Markus
AU - Knuf, Markus
AU - Schlag, Stephanie A.A.
AU - Liese, Johannes
AU - Renner, Lorna
AU - Enimil, Anthony
AU - Awunyo, Marah
AU - Syridou, Garyfallia
AU - Spyridis, Nikos
AU - Critselis, Elena
AU - Kouni, Sofia
AU - Mougkou, Katerina
AU - Ladomenou, Fani
AU - Gkentzi, Despoina
AU - Iosifidis, Elias
AU - Roilides, Emmanuel
AU - Sahu, Suneeta
AU - Murki, Srinivas
AU - Malviya, Manoj
AU - Kalavalapalli, Durga Bhavani
AU - Singh, Sanjeev
AU - Singhal, Tanu
AU - Garg, Garima
AU - Garg, Pankaj
AU - Kler, Neelam
AU - Soltani, Jafar
AU - Jafarpour, Zahra
AU - Pouladfar, Gholamreza
AU - Nicolini, Giangiacomo
AU - Montagnani, Carlotta
AU - Galli, Luisa
AU - Esposito, Susanna
AU - Vecchio, Andrea Lo
AU - Dona', Daniele
AU - Giaquinto, Carlo
AU - Borgia, Eleonora
AU - D'Argenio, Patrizia
AU - De Luca, Maia
AU - Centenari, Chiara
AU - Raka, Lul
AU - Omar, Abeer
AU - Al-Mousa, Haifaa
AU - Mozgis, Dzintars
AU - Sviestina, Inese
AU - Burokiene, Sigita
AU - Usonis, Vytautas
AU - Tavchioska, Gabriela
AU - Hargadon-Lowe, Antonia
AU - Zarb, Peter
AU - Borg, Michael A.
AU - González Lozano, Carlos Agustín
AU - Castañon, Patricia Zárate
AU - Cancino, Martha E.
AU - McCullagh, Bernadette
AU - McCorry, Ann
AU - Gormley, Cairine
AU - Al Maskari, Zaina
AU - Al-Jardani, Amina
AU - Pluta, Magdalena
AU - Rodrigues, Fernanda
AU - Brett, Ana
AU - Esteves, Isabel
AU - Marques, Laura
AU - AlAjmi, Jameela Ali
AU - Cambrea, Simona Claudia
AU - Rashed, Asia N.
AU - Al Azmi, Aeshah Abdu Mubarak
AU - Chan, Si Min
AU - Isa, Mas Suhaila
AU - Najdenov, Peter
AU - Čižman, Milan
AU - Unuk, Sibila
AU - Finlayson, Heather
AU - Dramowski, Angela
AU - Maté-Cano, Irene
AU - Soto, Beatriz
AU - Calvo, Cristina
AU - Santiago, Begoña
AU - Saavedra-Lozano, Jesus
AU - Bustinza, Amaya
AU - Escosa-García, Luis
AU - Ureta, Noelia
AU - Tagarro, Alfredo
AU - Barrero, Pedro Terol
AU - Rincon-Lopez, Elena Maria
AU - Abubakar, Ismaela
AU - Aston, Jeff
AU - Heginbothom, Maggie
AU - Satodia, Prakash
AU - Garbash, Mehdi
AU - Johnson, Alison
AU - Sharpe, David
AU - Barton, Christopher
AU - Menson, Esse
AU - Arenas-Lopez, Sara
AU - Luck, Suzanne
AU - Doerholt, Katja
AU - McMaster, Paddy
AU - Caldwell, Neil A.
AU - Lunn, Andrew
AU - Drysdale, Simon B.
AU - Howe, Rachel
AU - Scorrer, Tim
AU - Gahleitner, Florian
AU - Gupta, Richa
AU - Nash, Clare
AU - Alexander, John
AU - Raman, Mala
AU - Bell, Emily
AU - Rajagopal, Veena
AU - Kohlhoff, Stephan
AU - Cox, Elaine
AU - Zaoutis, Theoklis
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children.
AB - Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children.
UR - http://www.scopus.com/inward/record.url?scp=84964355485&partnerID=8YFLogxK
U2 - 10.1093/jac/dkv418
DO - 10.1093/jac/dkv418
M3 - Article
C2 - 26747104
AN - SCOPUS:84964355485
SN - 0305-7453
VL - 71
SP - 1106
EP - 1117
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 4
ER -
