The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia

James Smith, Jeffrey Braithwaite, Tracey A. O'Brien, Stephanie Smith, Vanessa J. Tyrell, Emily V. A. Mould, Janet Long, Frances Rapport

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.
Original languageEnglish
Pages (from-to)1865 - 1880
Number of pages16
JournalQualitative Health Research
Volume32
Issue number12
DOIs
Publication statusPublished - Oct 2022

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