TY - JOUR
T1 - The vital role of ATP citrate lyase in chronic diseases
AU - Khwairakpam, Amrita Devi
AU - Banik, Kishore
AU - Girisa, Sosmitha
AU - Shabnam, Bano
AU - Shakibaei, Mehdi
AU - Fan, Lu
AU - Arfuso, Frank
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Chronic or non-communicable diseases are the leading cause of death worldwide; they usually result in long-term illnesses and demand long-term care. Despite advances in molecular therapeutics, specific biomarkers and targets for the treatment of these diseases are required. The dysregulation of de novo lipogenesis has been found to play an essential role in cell metabolism and is associated with the development and progression of many chronic diseases; this confirms the link between obesity and various chronic diseases. The main enzyme in this pathway—ATP-citrate lyase (ACLY), a lipogenic enzyme—catalyzes the critical reaction linking cellular glucose catabolism and lipogenesis. Increasing lines of evidence suggest that the modulation of ACLY expression correlates with the development and progressions of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, inflammation, and cancer. Recent studies suggest that the inhibition of ACLY activity modulates the glycolysis and lipogenesis processes and stimulates normal physiological functions. This comprehensive review aimed to critically evaluate the role of ACLY in the development and progression of different diseases and the effects of its downregulation in the prevention and treatment of these diseases.
AB - Chronic or non-communicable diseases are the leading cause of death worldwide; they usually result in long-term illnesses and demand long-term care. Despite advances in molecular therapeutics, specific biomarkers and targets for the treatment of these diseases are required. The dysregulation of de novo lipogenesis has been found to play an essential role in cell metabolism and is associated with the development and progression of many chronic diseases; this confirms the link between obesity and various chronic diseases. The main enzyme in this pathway—ATP-citrate lyase (ACLY), a lipogenic enzyme—catalyzes the critical reaction linking cellular glucose catabolism and lipogenesis. Increasing lines of evidence suggest that the modulation of ACLY expression correlates with the development and progressions of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, inflammation, and cancer. Recent studies suggest that the inhibition of ACLY activity modulates the glycolysis and lipogenesis processes and stimulates normal physiological functions. This comprehensive review aimed to critically evaluate the role of ACLY in the development and progression of different diseases and the effects of its downregulation in the prevention and treatment of these diseases.
UR - http://www.scopus.com/inward/record.url?scp=85077060514&partnerID=8YFLogxK
U2 - 10.1007/s00109-019-01863-0
DO - 10.1007/s00109-019-01863-0
M3 - Review article
SN - 0946-2716
VL - 98
SP - 71
EP - 95
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 1
ER -
