The utility and limitations of 18F-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: Single institution experience and literature review

Chan Y. Cheah, Michael S. Hofman, John F. Seymour, David S. Ritchie, Michael Dickinson, Andrew Wirth, H. Miles Prince, Max Wolf, Elchanan H. Januszcewicz, Dennis A. Carney, Kirsten E. Herbert, Simon J. Harrison, Kate L. Burbury, Constantine S. Tam

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

There are limited data regarding the role of 18F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT) scanning in primary mediastinal B-cell lymphoma (PMBL). We analyzed 28 patients with PMBL treated with chemotherapy, of whom 25 (89%) also received rituximab and 17 (61%) radiotherapy. PET-CT scans were interpreted using visual analysis and a 5-point scale. After a median follow-up of 2.6 years, four patients relapsed and two died. The 2-year progression-free survival and overall survival were 86% and 94%. PET-CT has excellent negative predictive value (interim, 86-87%; end of treatment, 95%) but limited positive predictive value due to the high frequency of positive scans. Several patients with persistent metabolically active masses underwent biopsies, which showed necrosis but no lymphoma. Thus a negative PET-CT is an excellent predictor of subsequent outcome. However, residual metabolically active masses after treatment should be biopsied to confirm viable lymphoma prior to salvage therapy.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalLEUKEMIA & LYMPHOMA
Volume56
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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