The type 1 insulin-like growth factor receptor and resistance to DACH1

Tiziana DeAngelis; Kongming Wu; Richard Pestell; Renato Baserga

doi:10.4161/cc.10.12.15800

The type 1 insulin-like growth factor receptor and resistance to DACH1

Tiziana DeAngelis, Kongming Wu, Richard Pestell, Renato Baserga

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The mammalian homolog of the Drosophila dachshund gene (DACH1) has been reported as a tumor suppressor in human breast and prostate cancers. It downregulates the epidermal growth factor receptor (EGFR) and cyclin D1. The signaling pathway of the type 1 insulin-like growth factor receptor (IGF-IR) is known to be responsible for the development of resistance to treatment of human cancer with antibodies to the EGFR. We have asked whether DACH1 still exerts its tumor suppressor activity in cells dependent on the IGF-IR for growth. We find that in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity.

Original language	English
Pages (from-to)	1956-1959
Number of pages	4
Journal	Cell Cycle
Volume	10
Issue number	12
DOIs	https://doi.org/10.4161/cc.10.12.15800
Publication status	Published - 15 Jun 2011
Externally published	Yes

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abstract = "The mammalian homolog of the Drosophila dachshund gene (DACH1) has been reported as a tumor suppressor in human breast and prostate cancers. It downregulates the epidermal growth factor receptor (EGFR) and cyclin D1. The signaling pathway of the type 1 insulin-like growth factor receptor (IGF-IR) is known to be responsible for the development of resistance to treatment of human cancer with antibodies to the EGFR. We have asked whether DACH1 still exerts its tumor suppressor activity in cells dependent on the IGF-IR for growth. We find that in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity.",

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AU - Pestell, Richard

AU - Baserga, Renato

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AB - The mammalian homolog of the Drosophila dachshund gene (DACH1) has been reported as a tumor suppressor in human breast and prostate cancers. It downregulates the epidermal growth factor receptor (EGFR) and cyclin D1. The signaling pathway of the type 1 insulin-like growth factor receptor (IGF-IR) is known to be responsible for the development of resistance to treatment of human cancer with antibodies to the EGFR. We have asked whether DACH1 still exerts its tumor suppressor activity in cells dependent on the IGF-IR for growth. We find that in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity.

KW - Resistance to therapy

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KW - Type 1 IGF-1 receptor

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The type 1 insulin-like growth factor receptor and resistance to DACH1

Abstract

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