Hypopigmcntation may be a significant problem after burn injury. It is often difficult to predicably repair with conventional surgical techniques. It has been our experience that epidermal cells cultured from patients with dark skin produce pigment within the epidermal cell sheets, which indicates the presence of mclanocytes. The presence of mclanocytes and melanin in these cell sheets was demonstrated with the use of histochemical techniques. The results indicate that repigmentation with cultured epithelial autograft is possible. We describe a novel technique of dermabrasion and a co-culture of epidermal cells and mclanocytes. (J Burn Care Rehabil 2000;21:50-4).