The transcriptional response to hypoxic insult controlled by FRA-2

Tanya L. Butler, Keith R. Pennypacker

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


FRA-2 is involved in cellular differentiation and is also upregulated in response to ischemic injury to the brain. To shed light on the function of this transcription factor, a novel microarray analysis was utilized to identify FRA-2-dependent gene expression increased in the hypoxic response. Genes were identified that were upregulated by exposure of neuronally differentiated PC12 cells to hypoxia. Using a dominant negative construct to block FRA-2, a second subset of genes that were FRA-2 dependent was found. Cross comparison then allowed isolation of a list of genes that were induced in response to hypoxia in a FRA-2-dependent manner. These data suggest that FRA-2 is involved in the transcriptional control of neuroprotective genes and in the switch from aerobic to anaerobic metabolism.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalGene expression
Issue number2
Publication statusPublished - 2004
Externally publishedYes


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