The thyroid stimulating hormone receptor in human disease

L. C. Harrison, P. J. Leedman

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The initial step in the action of thyrotropin (TSH) is its binding to the TSH receptor. TSH receptor antibodies are detected in up to 90% of patients with Graves' disease. Serial measurements of TSH receptor antibodies in patients with Graves' hyperthyroidism are helpful in predicting relapse. The TSH receptor was purified using affinity chromatography on wheat germ lectin agarose and TSH-agarose. Using an immunoblotting technique to characterize the TSH receptor, it was found to be an oligomeric glycoprotein consisting of three noncovalently bound subunits of Mr ∼ 70,000, ∼ 50,000 and ∼ 35,000 which on reduction yield a single subunit of Mr ∼ 25,000.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalClinical Biochemistry
Issue number1
Publication statusPublished - Feb 1990
Externally publishedYes


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