TY - JOUR
T1 - The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases
AU - Sharif, A
AU - Mamo, J
AU - Lam, V
AU - Al-Salami, H
AU - Mooranian, A
AU - Watts, GF
AU - Clarnette, R
AU - Luna, G
AU - Takechi, R
PY - 2024
Y1 - 2024
N2 - Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood-brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies. Emerging research indicates that probucol, a historic lipid-lowering medication, offers substantial potential in the realm of neurodegenerative disease prevention and treatment. Preclinical investigations have unveiled multifaceted cellular effects of probucol, showcasing its remarkable antioxidative and anti-inflammatory properties, its ability to fortify the BBB and its direct influence on neural preservation and adaptability. These diverse effects collectively translate into enhancements in both motor and cognitive functions. This review provides a comprehensive overview of recent findings highlighting the efficacy of probucol and probucol-related compounds in the context of various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and cognitive impairment associated with diabetes.
AB - Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood-brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies. Emerging research indicates that probucol, a historic lipid-lowering medication, offers substantial potential in the realm of neurodegenerative disease prevention and treatment. Preclinical investigations have unveiled multifaceted cellular effects of probucol, showcasing its remarkable antioxidative and anti-inflammatory properties, its ability to fortify the BBB and its direct influence on neural preservation and adaptability. These diverse effects collectively translate into enhancements in both motor and cognitive functions. This review provides a comprehensive overview of recent findings highlighting the efficacy of probucol and probucol-related compounds in the context of various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and cognitive impairment associated with diabetes.
KW - Amyloid-beta
KW - Blood-brain barrier
KW - Inflammation
KW - Neurodegenerative disease
KW - Oxidative stress
KW - Probucol
KW - Probucol analogues
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uwapure5-25&SrcAuth=WosAPI&KeyUT=WOS:001146026900001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1186/s40035-024-00398-w
DO - 10.1186/s40035-024-00398-w
M3 - Review article
C2 - 38247000
SN - 2047-9158
VL - 13
JO - Translational Neurodegeneration
JF - Translational Neurodegeneration
IS - 1
M1 - 6
ER -
