The temperature dependent changes in the terahertz absorption spectrum due to the self-assembly of quadruplexes in a solution of the nucleoside guanosine monophosphate

Yu Heng Tao, Simon Schulke, Gerhard Schwaab, Steffen Murke, Simone Pezzotti, Stuart Hodgetts, Alan Harvey, Vincent P. Wallace, Martina Havenith

Research output: Chapter in Book/Conference paperConference paperpeer-review

Abstract

The self-assembly of the nucleoside guanosine monophosphate (GMP) into complex DNA secondary structures, in aqueous solution is concentration and temperature dependent. It is a unique phenomenon that provides a basis for studying more complicated structures related to DNA. In the present study, we show that distinct features in the terahertz spectrum (30 to 400 cm-1, 0.8 - 12 THz) are associated with the formation of GMP dimers and quadruplexes, and that these can be attributed to changes in the hydration water and intra-molecular modes of the aggregated structures. This finding establishes a basis for further investigation into secondary DNA structures using terahertz radiation, such as G-quadruplex and i-motif.

Original languageEnglish
Title of host publicationIRMMW-THz 2023 - 48th Conference on Infrared, Millimeter, and Terahertz Waves
PublisherIEEE, Institute of Electrical and Electronics Engineers
ISBN (Electronic)9798350336603
DOIs
Publication statusPublished - 2023
Event48th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2023 - Montreal, Canada
Duration: 17 Sept 202322 Sept 2023

Publication series

NameInternational Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
ISSN (Print)2162-2027
ISSN (Electronic)2162-2035

Conference

Conference48th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2023
Country/TerritoryCanada
CityMontreal
Period17/09/2322/09/23

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