Part I describes the synthesis and pharmacological evaluation of antibacterial compound 135C. A range of synthetic, microbiological and genomic approaches were lakenas an attempt to elucidate Its mode or action, which may be related to the disruption of the biosynthetlc pathway of cell wall teichoic acids. Part II describes the use of new air-stable nickel(0) complexes as catalysts in cross-coupling reactions, a process that normally utilises expensive palladium or air-sensitive nickel(0) complexes. In this thesis, nickel(0) phosphiles were trialled for their ability lo catalyse the C-C bond forming Mizoroki-Heck & Suzuki-Miyaura cross-coupling reactions.
|Qualification||Doctor of Philosophy|
|Award date||30 Jan 2018|
|Publication status||Unpublished - 2018|