The synthesis and pharmacological studies on a novel antimicrobial agent and new nickel catalysts and their applications in organic synthesis

Nikki Ying-Tung Man

Research output: ThesisDoctoral Thesis

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Abstract

Part I describes the synthesis and pharmacological evaluation of antibacterial compound 135C. A range of synthetic, microbiological and genomic approaches were lakenas an attempt to elucidate Its mode or action, which may be related to the disruption of the biosynthetlc pathway of cell wall teichoic acids. Part II describes the use of new air-stable nickel(0) complexes as catalysts in cross-coupling reactions, a process that normally utilises expensive palladium or air-sensitive nickel(0) complexes. In this thesis, nickel(0) phosphiles were trialled for their ability lo catalyse the C-C bond forming Mizoroki-Heck & Suzuki-Miyaura cross-coupling reactions.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Stewart, Scott, Supervisor
  • McKinley, Allan, Supervisor
  • Hammer, Kate, Supervisor
  • Riley, Thomas, Supervisor
Thesis sponsors
Award date30 Jan 2018
DOIs
Publication statusUnpublished - 2018

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Anti-Infective Agents
Nickel
Catalysts
Teichoic Acids
Palladium
Air
Cells

Cite this

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AB - Part I describes the synthesis and pharmacological evaluation of antibacterial compound 135C. A range of synthetic, microbiological and genomic approaches were lakenas an attempt to elucidate Its mode or action, which may be related to the disruption of the biosynthetlc pathway of cell wall teichoic acids. Part II describes the use of new air-stable nickel(0) complexes as catalysts in cross-coupling reactions, a process that normally utilises expensive palladium or air-sensitive nickel(0) complexes. In this thesis, nickel(0) phosphiles were trialled for their ability lo catalyse the C-C bond forming Mizoroki-Heck & Suzuki-Miyaura cross-coupling reactions.

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KW - bacteriology

KW - nickel catalysis

KW - cross-coupling reactions

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KW - pharmacological studies

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