The synthesis and fluorescence profile of novel thalidomide analogues

Sven Kampmann, Brian Skelton, George Yeoh, Lawrence Abraham, N.A. Lengkeek, Keith Stubbs, Charles Heath, Scott Stewart

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Copyright © 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.
Original languageEnglish
Pages (from-to)8140-8149
Number of pages10
Issue number42
Early online date20 Aug 2015
Publication statusPublished - 21 Oct 2015


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