The synthesis and fluorescence profile of novel thalidomide analogues

Sven Kampmann; Brian Skelton; George Yeoh; Lawrence Abraham; N.A. Lengkeek; Keith Stubbs; Charles Heath; Scott Stewart

doi:10.1016/j.tet.2015.08.036

The synthesis and fluorescence profile of novel thalidomide analogues

Sven Kampmann, Brian Skelton, George Yeoh, Lawrence Abraham, N.A. Lengkeek, Keith Stubbs, Charles Heath, Scott Stewart

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Copyright © 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.

Original language	English
Pages (from-to)	8140-8149
Number of pages	10
Journal	Tetrahedron
Volume	71
Issue number	42
Early online date	20 Aug 2015
DOIs	https://doi.org/10.1016/j.tet.2015.08.036
Publication status	Published - 21 Oct 2015

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10.1016/j.tet.2015.08.036

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abstract = "Copyright {\textcopyright} 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.",

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AU - Kampmann, Sven

AU - Skelton, Brian

AU - Yeoh, George

AU - Abraham, Lawrence

AU - Lengkeek, N.A.

AU - Stubbs, Keith

AU - Heath, Charles

AU - Stewart, Scott

PY - 2015/10/21

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AB - Copyright © 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.

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DO - 10.1016/j.tet.2015.08.036

M3 - Article

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SP - 8140

EP - 8149

JO - Tetrahedron

JF - Tetrahedron

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The synthesis and fluorescence profile of novel thalidomide analogues

Abstract

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