Abstract
Copyright © 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.
Original language | English |
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Pages (from-to) | 8140-8149 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 71 |
Issue number | 42 |
Early online date | 20 Aug 2015 |
DOIs | |
Publication status | Published - 21 Oct 2015 |