Copyright © 2015 Published by Elsevier Ltd. All rights reserved. Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.
|Number of pages||10|
|Early online date||20 Aug 2015|
|Publication status||Published - 21 Oct 2015|