The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc

Adrian Scaffidi; Keith Stubbs; D.J. Vocadlo; Robert Stick

doi:10.1016/j.carres.2008.08.012

The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc

Adrian Scaffidi, Keith Stubbs, D.J. Vocadlo, Robert Stick

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2744-2753
Journal	Carbohydrate Research
Volume	343
DOIs	https://doi.org/10.1016/j.carres.2008.08.012
Publication status	Published - 2008

Access to Document

10.1016/j.carres.2008.08.012

Fingerprint Dive into the research topics of 'The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc'. Together they form a unique fingerprint.

Cite this

@article{6bbe28ec521e44c99a615d9e7082f8a7,

title = "The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc",

abstract = "The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.",

author = "Adrian Scaffidi and Keith Stubbs and D.J. Vocadlo and Robert Stick",

year = "2008",

doi = "10.1016/j.carres.2008.08.012",

language = "English",

volume = "343",

pages = "2744--2753",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier",

}

TY - JOUR

T1 - The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc

AU - Scaffidi, Adrian

AU - Stubbs, Keith

AU - Vocadlo, D.J.

AU - Stick, Robert

PY - 2008

Y1 - 2008

N2 - The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.

AB - The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.carres.2008.08.012

DO - 10.1016/j.carres.2008.08.012

M3 - Article

VL - 343

SP - 2744

EP - 2753

JO - Carbohydrate Research

JF - Carbohydrate Research

SN - 0008-6215

ER -