TY - JOUR
T1 - The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc
AU - Scaffidi, Adrian
AU - Stubbs, Keith
AU - Vocadlo, D.J.
AU - Stick, Robert
PY - 2008
Y1 - 2008
N2 - The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.
AB - The synthesis of some analogues of O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of beta-N-acetylglucosaminidases, is described. The analogues were tested against a range of beta-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-D-glucosamine. (C) 2008 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.carres.2008.08.012
DO - 10.1016/j.carres.2008.08.012
M3 - Article
VL - 343
SP - 2744
EP - 2753
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
ER -