TY - GEN
T1 - The study of the terahertz absorption spectrum of G-Quadruplex
AU - Tao, Yu Heng
AU - Nealon, Gareth
AU - Hodgetts, Stuart I.
AU - Harvey, Alan R.
AU - Wallace, Vincent P.
N1 - Publisher Copyright:
© 2022 IEEE.
PY - 2022/9/26
Y1 - 2022/9/26
N2 - The secondary structures of nucleic acids are crucial to the regulation of genomic activities, and could potentially serve as a marker for some cancers. Question remains whether such structures could have distinct absorption features in the terahertz range, including a 1.6 THz peak absorption previously reported in methylated DNA. In this study, we examine the terahertz absorption spectrum of G-quadruplex (G4), a key secondary DNA structure that has been closely linked to cancer. The results show that in its most basic form, made up of self-assembled guanosine monophosphate (GMP), there are no distinct features. This result provides a reference for our ongoing investigation on other secondary structures of nucleic acids, and suggests that abnormal population of G4, as found in some cancers, may not be detectable via terahertz absorption spectroscopy.
AB - The secondary structures of nucleic acids are crucial to the regulation of genomic activities, and could potentially serve as a marker for some cancers. Question remains whether such structures could have distinct absorption features in the terahertz range, including a 1.6 THz peak absorption previously reported in methylated DNA. In this study, we examine the terahertz absorption spectrum of G-quadruplex (G4), a key secondary DNA structure that has been closely linked to cancer. The results show that in its most basic form, made up of self-assembled guanosine monophosphate (GMP), there are no distinct features. This result provides a reference for our ongoing investigation on other secondary structures of nucleic acids, and suggests that abnormal population of G4, as found in some cancers, may not be detectable via terahertz absorption spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=85139818184&partnerID=8YFLogxK
U2 - 10.1109/IRMMW-THz50927.2022.9895767
DO - 10.1109/IRMMW-THz50927.2022.9895767
M3 - Conference paper
AN - SCOPUS:85139818184
T3 - International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
BT - IRMMW-THz 2022 - 47th International Conference on Infrared, Millimeter and Terahertz Waves
PB - IEEE, Institute of Electrical and Electronics Engineers
T2 - 47th International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2022
Y2 - 28 August 2022 through 2 September 2022
ER -