The study of the terahertz absorption spectrum of G-Quadruplex

Research output: Chapter in Book/Conference paperConference paperpeer-review

Abstract

The secondary structures of nucleic acids are crucial to the regulation of genomic activities, and could potentially serve as a marker for some cancers. Question remains whether such structures could have distinct absorption features in the terahertz range, including a 1.6 THz peak absorption previously reported in methylated DNA. In this study, we examine the terahertz absorption spectrum of G-quadruplex (G4), a key secondary DNA structure that has been closely linked to cancer. The results show that in its most basic form, made up of self-assembled guanosine monophosphate (GMP), there are no distinct features. This result provides a reference for our ongoing investigation on other secondary structures of nucleic acids, and suggests that abnormal population of G4, as found in some cancers, may not be detectable via terahertz absorption spectroscopy.
Original languageEnglish
Title of host publicationIRMMW-THz 2022 - 47th International Conference on Infrared, Millimeter and Terahertz Waves
PublisherIEEE, Institute of Electrical and Electronics Engineers
ISBN (Electronic)9781728194271
DOIs
Publication statusPublished - 26 Sept 2022
Event47th International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2022 - Delft, Netherlands
Duration: 28 Aug 20222 Sept 2022

Publication series

NameInternational Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Volume2022-August
ISSN (Print)2162-2027
ISSN (Electronic)2162-2035

Conference

Conference47th International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2022
Country/TerritoryNetherlands
CityDelft
Period28/08/222/09/22

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