The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System

M.E.C. Caines, S.M. Hancock, C.A. Tarling, T.M. Wrodnigg, Robert Stick, A.E. Stutz, A. Vasella, S.G. Withers, N.C.J. Strynadka

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36 Citations (Scopus)

Abstract

Fitting five into six: The crystal structure of a glycosidase-bound, five-membered iminocyclitol inhibitor was determined (see picture), and its binding interactions were compared to those of the classical six-membered iminocyclitol inhibitors isofagomine and glucoimidazole and of the glycosyl–enzyme intermediate. This information may be used to develop more potent and specific therapeutically useful glycosidase inhibitors.
Original languageEnglish
Pages (from-to)4474-4476
JournalAngewandte Chemie (International Edition)
Volume46
Issue number24
DOIs
Publication statusPublished - 2007

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