The Selective Pulmonary Vasodilatory Effect of Inhaled DETA/NO, a Novel Nitric Oxide Donor, in ARDS - A Pilot Human Trial

C-F. Lam, Peter Van Heerden, J. Blott, B. Roberts, Kenneth Ilett

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Obiectives: To examine the effects of inhaled NONO-ates in patients with acute respiratory distress syndrome (ARDS).Design: Case-series, phase I clinical trial.Setting: A multidisciplinary intensive care unit in a tertiary teaching hospital. Patients: Five consecutive patients with ARDS (men; age range, 47-76 years).Measurements: DETA/NO (150 mumol) was aerosolized into the lungs of patients on mechanical ventilation via the endotracheal tube over 20 minutes. Hemodynamic parameters were measured and blood samples were taken before, during, and after inhalation.Results: Compared to baseline values, pulmonary vascular resistance decreased until the end of the study period (180 minutes) while intrapulmonary shunting decreased significantly up to 45 min after DETA/NO aerosol administration. Inhaled DETA/NO had no effect on the systemic circulation (systemic blood pressure or cardiac output).Conclusions: Inhaled DETA/NO is a selective pulmonary vasodilator in patients with ARDS. However, a larger number of patients is required to confirm the findings of this pilot study. (C) 2004 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)48-53
JournalJournal of Critical Care
Volume19
Issue number1
DOIs
Publication statusPublished - 2004

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