The scent of Mycobacterium tuberculosis - Part II breath

M. Syhre, S. Phuanukoonnon, Laurens Manning, S.T. Chambers

    Research output: Contribution to journalArticlepeer-review

    115 Citations (Scopus)

    Abstract

    Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.
    Original languageEnglish
    Pages (from-to)263-266
    JournalTuberculosis
    Volume89
    Issue number4
    DOIs
    Publication statusPublished - 2009

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