The roles of inhibin and GnRH in the control of LH and FSH secretion in the ewe

G.B. Martin, J.M. Wallace, P.L. Taylor, H.M. Fraser, A.S. Mcneilly

Research output: Chapter in Book/Conference paperConference paperpeer-review


The roles of ovarian inhibition and hypothalamic stimulation in the differential control of FSH and LH secretion were investigated in the ewe by studying the responses to ovariectomy, passive immunization against GnRH, and treatment with inhibin and GnRH analogue. The results of these experiments led us to conclude that LH release is acutely controlled by hypothalamic stimulation and chronically controlled by ovarian feedback on the pituitary gland, whereas FSH release is controlled chronically by changes in hypothalamic stimulation and acutely by ovarian feedback at pituitary level. Inhibin is an important component of this feedback on FSH release.
Original languageEnglish
Title of host publicationLes récepteurs hormonaux dans la reproduction de la biologie à la clinique
Subtitle of host publicationColloque de la Société Française pour l'Etude de la Fertilité
Place of PublicationParis
PublisherElsevier Masson s.r.l.
Publication statusPublished - 1987


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