The role of vitamin D in gastrointestinal inflammation

Simon Ghaly, Ian Lawrance

    Research output: Contribution to journalReview article

    22 Citations (Scopus)

    Abstract

    © 2014 Informa UK Ltd. The emerging role of vitamin D as a regulator of both innate and adaptive immune responses has encouraged the investigation of its role in the pathogenesis of a variety of autoimmune conditions including the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Animal models consistently demonstrate that vitamin D significantly impacts on the modulation of astrointestinal inflammation, while epidemiological and observational data show an inverse relationship between vitamin D status and the onset/progression of Crohn's disease as well as the development of colorectal cancer. As vitamin D supplementation is readily available, at low cost, it is a very attractive potential therapeutic option. The biological plausibility for a role for vitamin D in inflammation modulation, the potential genetic links associated with vitamin D metabolism and the clinical aspects for it in IBD will be discussed.
    Original languageEnglish
    Pages (from-to)909-923
    JournalExpert Review of Gastroenterology and Hepatology
    Volume8
    Issue number8
    DOIs
    Publication statusPublished - 2014

      Fingerprint

    Cite this