The role of vitamin D and ultraviolet radiation in inflammatory bowel disease

Simon Ghaly

Research output: ThesisDoctoral Thesis

297 Downloads (Pure)

Abstract

Vitamin D deficiency is associated with active Crohn's disease (CD) and ulcerative colitis, but it is not known if this is causal. We observed that vitamin D levels did not predict disease flares in CD and treatment of active CD led to a spontaneous rise in vitamin D levels. In murine colitis, vitamin D dropped significantly and mice on high vitamin D-containing diets demonstrated distinct faecal microbiome changes and also developed worse colitis. Taken together, these data suggest that vitamin D deficiency is a result rather than cause of intestinal inflammation and vitamin D supplementation is not protective.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Hart, Prudence, Supervisor
  • Lawrance, Ian, Supervisor
Thesis sponsors
Award date10 Aug 2019
DOIs
Publication statusUnpublished - 2019

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