The role of the host-microbiome and metabolomics in sarcoidosis

Junwoo Kim, Silvia Lee, Yuben Moodley, Lokesh Yagnik, David Birnie, Girish Dwivedi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Sarcoidosis is a complex inflammatory fibrotic disease that affects multiple organ systems. It is characterised by the infiltration of lymphocytes and mononuclear phagocytes, which form non-caseating granulomas in affected organs. The lungs and intrathoracic lymph nodes are the most commonly affected organs. The underlying cause of sarcoidosis is unknown, but it is believed to occur in genetically predisposed individuals who are exposed to pathogenic organisms, environmental contaminants, or self and non-self-antigens. Recent research has suggested that the microbiome may play a role in the development of respiratory conditions, including sarcoidosis. Additionally, metabolomic studies have identified potential biomarkers for monitoring sarcoidosis progression. This review will focus on recent microbiome and metabolomic findings in sarcoidosis, with the goal of shedding light on the pathogenesis and possible diagnostic and therapeutic approaches.

Original languageEnglish
Pages (from-to)C1336-C1353
JournalAmerican journal of physiology. Cell physiology
Volume325
Issue number5
DOIs
Publication statusPublished - 1 Nov 2023

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