The role of the gut microbiome and associated metabolites in cardiovascular disease

Adilah Ahmad Hari Thas

Research output: ThesisDoctoral Thesis

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Abstract

This cross-sectional study investigated the gut microbiome profile and its associated bacterial metabolites in patients with acute coronary syndrome and heart failure compared to healthy controls. Altered differential abundances in gut microbiota composition and bacterial metabolites were seen in CVD patients compared to healthy controls, along with an increased inflammatory state and different plasma metabolome and lipidome. These results suggest changes in the gut microbiome and metabolites may contribute to the development and progression of CVD. These findings have clinical implications and may facilitate the future development of therapeutic strategies targeting the microbiome through personalized medicine approaches.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Ward, Natalie, Supervisor
  • Dwivedi, Girish, Supervisor
  • Caparros-Martin, Jose A., Supervisor, External person
  • O’Gara, Fergal, Supervisor, External person
Award date27 Oct 2023
DOIs
Publication statusUnpublished - 2023

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