The Role of the Gut in the Pathogenesis of Parkinson’s Disease: from Human Genetics to Epithelial α-Synuclein

Anastazja Gorecki

Research output: ThesisDoctoral Thesis

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Abstract

Parkinson’s disease (PD) is a neurological disorder linked to gut dysfunction, inflammation and microbial dysbiosis. Despite being an important regulator of gut homeostasis and host-microbe interactions, the intestinal barrier is neglected in PD research. This thesis used various techniques to investigate the contribution of the gut to PD, focussing on epithelial α-synuclein. Taken together, the results of this thesis: 1) demonstrate that PD risk is modulated by genetic variants regulating host microbe interactions at the gut barrier; 2) further characterise α-synuclein in gastrointestinal epithelial cell populations and 3) highlight a potential therapeutic which can mitigate α-synuclein pathology in the gut.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Rodger, Jennifer, Supervisor
  • Dunlop, Sarah, Supervisor
  • Kulkarni , Subhash, Supervisor, External person
  • Anderton, Ryan, Supervisor, External person
Thesis sponsors
Award date26 Jun 2023
DOIs
Publication statusUnpublished - 2023

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