The Role of Subchondral Bone Integrity in Articular Cartilage Repair

Aswin Beck

Research output: ThesisDoctoral Thesis

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Abstract

The role of subchondral bone integrity in articular cartilage repair remains unclear. In a preclinical articular cartilage model, penetration of the subchondral bone plate below the defect area resulted in subchondral bone cyst formation. Aspiration of bone marrow from the intercondylar notch as a subchondral bone-sparing technique and implantation into the cartilage defect did not prevent cyst formation and did not improve cartilage healing. Retrospective analysis of clinically failed Matrix-Assisted Chondrocyte Implantation (MACI) specimens demonstrated failure of the osteochondral unit, rather than failure of cartilage repair tissue. Subchondral bone integrity appears important in articular cartilage repair techniques.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Zheng, Minghao, Supervisor
  • Wood, David, Supervisor
Thesis sponsors
Award date30 Mar 2021
DOIs
Publication statusUnpublished - 2021

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