The Role of Subchondral Bone Integrity in Articular Cartilage Repair

Aswin Beck

doi:10.26182/229k-5203

The Role of Subchondral Bone Integrity in Articular Cartilage Repair

Aswin Beck

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

The role of subchondral bone integrity in articular cartilage repair remains unclear. In a preclinical articular cartilage model, penetration of the subchondral bone plate below the defect area resulted in subchondral bone cyst formation. Aspiration of bone marrow from the intercondylar notch as a subchondral bone-sparing technique and implantation into the cartilage defect did not prevent cyst formation and did not improve cartilage healing. Retrospective analysis of clinically failed Matrix-Assisted Chondrocyte Implantation (MACI) specimens demonstrated failure of the osteochondral unit, rather than failure of cartilage repair tissue. Subchondral bone integrity appears important in articular cartilage repair techniques.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Zheng, Minghao, Supervisor Wood, David, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	30 Mar 2021
DOIs	https://doi.org/10.26182/229k-5203
Publication status	Unpublished - 2021

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10.26182/229k-5203

THESIS - DOCTOR OF PHILOSOPHY - BECK, Aswin - 2021
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Cite this

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title = "The Role of Subchondral Bone Integrity in Articular Cartilage Repair",

abstract = "The role of subchondral bone integrity in articular cartilage repair remains unclear. In a preclinical articular cartilage model, penetration of the subchondral bone plate below the defect area resulted in subchondral bone cyst formation. Aspiration of bone marrow from the intercondylar notch as a subchondral bone-sparing technique and implantation into the cartilage defect did not prevent cyst formation and did not improve cartilage healing. Retrospective analysis of clinically failed Matrix-Assisted Chondrocyte Implantation (MACI) specimens demonstrated failure of the osteochondral unit, rather than failure of cartilage repair tissue. Subchondral bone integrity appears important in articular cartilage repair techniques.",

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AB - The role of subchondral bone integrity in articular cartilage repair remains unclear. In a preclinical articular cartilage model, penetration of the subchondral bone plate below the defect area resulted in subchondral bone cyst formation. Aspiration of bone marrow from the intercondylar notch as a subchondral bone-sparing technique and implantation into the cartilage defect did not prevent cyst formation and did not improve cartilage healing. Retrospective analysis of clinically failed Matrix-Assisted Chondrocyte Implantation (MACI) specimens demonstrated failure of the osteochondral unit, rather than failure of cartilage repair tissue. Subchondral bone integrity appears important in articular cartilage repair techniques.

KW - subchondral bone

KW - microCT

KW - microfracture

KW - subchondral bone cyst

KW - AMIC

KW - MACI

U2 - 10.26182/229k-5203

DO - 10.26182/229k-5203

M3 - Doctoral Thesis

ER -

The Role of Subchondral Bone Integrity in Articular Cartilage Repair

Abstract

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