Macrophages are immune cells critical for tissue development and homeostasis. They also contribute to the pathogenesis of many chronic diseases, including cancer progression to metastasis. macrophage motility, regulated by colony stimulating factor-1 (CSF-1), is necessary for both their beneficial and deleterious functions. Src family kinases (SFKs) are thought to be recruited to the CSF-1 receptor (CSF-1R), however their specific role in CSF-1R signalling to macrophage motility and invasion is unclear. This study demonstrates a critical role for the SFKs, particularly Hck, in CSF-1R-mediated macrophage motility and invasion, and thus identifies Hck as a potential target for inhibition of macrophage motility.
|Qualification||Doctor of Philosophy|
|Award date||15 Sept 2016|
|Publication status||Unpublished - 2016|